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Sulfamazine sodium for the treatment of systemic infection in the sulfonamide, antibacterial spectrum, for most gram-positive and gram-negative bacteria are inhibitory, can through the blood-brain barrier into the cerebrospinal fluid, especially for streptococcus (streptococcus meningitis, streptococcus pneumonia, hemolptococcus) and toxoplasma effect is better, is the first choice for the treatment of toxoplasma.
Item NO.:
CAS NO. 547-32-0Color:
White to Off-White powderPackage:
25 Kg/DrumDescription
Sulfadiazine sodium is a milky white crystalline powder that is odourless and somewhat bitter in taste. It is soluble in a small amount of DMSO and methanol solution and is hygroscopic.
Specification
|
Item |
Specification |
|
Appearance |
White or almost white crystalline or powder |
|
ldentification A |
The infrared absorption spectrum concordant with the spectrum of sulfadiazine CRS |
|
ldentification B |
Test for sodium |
|
Solubility |
Freely soluble in water,slightly soluble in alcohol |
|
Heavy Metals |
Not more than 10 ppm |
|
Melting range |
250°℃-254℃ |
|
Clarity of the solution |
Clear |
|
Acidity |
PH=9.6-10.5 |
|
Selenium |
Not more than 30 ppm |
|
Loss on drying |
Not more than 0.5% |
|
Assay |
NMT100.5%ofCmHsN:O₂NaS calculated on the dried basis |
Application
Sulfadiazine sodium is mainly used in the treatment of patients with meningitis caused by sensitive Neisseria meningitidis. It can also be used to treat:
1.Acute bronchitis and mild pneumonia caused by haemophilus influenzae, Streptococcus pneumoniae and other streptococci.
2. Serocatosis.
3. Adjuncts to the treatment of chloroquine-resistant falciparum malaria.
4. Combination drugs with pyrimethamine for toxoplasmosis caused by Toxoplasma gondii in mice.
Pharmacological action and the mechanism of action
Sulfadiazine sodium is a medium acting sulfonamide antibacterial drug, which has antibacterial effect on many G + and G-bacteria. In addition, in vitro activity against Chlamydia trachomatis, N. stellca, Plasmodium and T. gondii. However, in recent years, the resistance of bacteria to this product has increased, especially streptococcus, Neisseria and Enterobacteriaceae bacteria. For the meningitis caused by sensitive Neisseria meningitidis, sensitive to Haemophilus influenzae, Streptococcus pneumoniae and other streptococcus bacteria caused by acute bronchitis or mild pneumonia, Nucelatosis, and chloroquine-resistant treatment of falciparum malaria, combined with pyrimethamine in the treatment of toxoplasmosis caused by T. gondii.
untoward effect
Anaphylaxis is common and has cross-allergic reactions with sulfonamides. Serious adverse reactions caused by it are rare, but fatal, such as exudative erythema multiforme, exfoliative dermatitis, bulmolysis atrophic dermatitis, fulminant hepatic necrosis, granulocytosis, aplastic anemia and other hematological abnormalities
FAQ
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A:Usually we will arrange the shipment in 7 -15 days.
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A: Yes, we offer technical support and guidance to our customers. Our team of experts can provide formulation advice, usage instructions, and answer any technical questions you may have about our Veternary APIs.
Q: Do you offer customization or private labeling of Veternary APIs?
A: Yes, we offer customization and private labeling services for Veternary APIs. Please contact our sales team for more information on how we can tailor our products to meet your specific needs.
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