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Norfloxacin is a fluoroquinolone antibacterial drug with broad-spectrum antimicrobial effect, especially high antibacterial activity against aerobic gram-negative bacilli. It is widely used in aquaculture and poultry breeding.
Item NO.:
CAS NO. 70458-96-7Color:
White to yellow in a crystalline powderPackage:
25 Kg/DrumDescription
The anti-infective drug norfloxacin, alias haloperate, is a common drug used in the treatment of intestinal infections. Norfloxacin has high antibacterial activity against Gram-negative bacteria such as Escherichia coli, Bacillus dysenterum, Salmonella, Proteus, Pseudomonobacterium aeruginosa, and also has good antibacterial effects against Gram-positive bacteria such as staphylococcus and Dicococcus pneumoniae. The main action site is the bacterial DNA gyrase, which makes the bacterial DNA spiral crack, quickly inhibit the growth and reproduction of bacteria, kill bacteria, and has a strong infiltration effect on the cell wall, so its bactericidal effect is stronger and less stimulation to the gastric mucosa.
Specification
|
Item |
Specification |
|
Description |
White to pale yellow crystalline powder, sensitive to light and moisture |
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solubility |
Slightly soluble in acetone,in water,and in alcohol;freely soluble in acetic acid, sparingly soluble in chloroform;very slightly soluble in methanol and in ethylacetate; insoluble in ether |
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Identification |
(A) IR absorption-positive (B) The retention time of the major peak of the sample solution corresponds to that of the standard solution, as obtained in the Assay |
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Impurity K |
≤0.15% |
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Impurity E |
≤0.15% |
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Impurity A |
≤0.10% |
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Impurity H |
≤0.10% |
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unidentified |
≤0.10% |
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Total impurities |
≤0.5% |
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Heavy metals |
≤0.0015% |
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Loss on drying |
≤1.0% |
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Residue on ignition |
≤0.1% |
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Assay(on dried basis) |
98.0%-102.0% |
Application
For infectious diseases such as urinary tract, intestine, otolaryngology, otolaryngology, gynecology, surgery and dermatology caused by sensitive bacteria, indications
1. urogenital tract infection: simple, complicated urinary tract infection, bacterial prostatitis, gonococcal urinary tract infection and germ line infection.
2. gastrointestinal tract infection.
3.typhoid fever and other Salmonella infections. Fluoperate is a concentration-dependent drug, that is, the concentration of the drug in the body is proportional to the efficacy, and the higher the concentration, the better the efficacy. Because food will delay the absorption rate of fludol in the human body, the blood concentration of taking medicine on an empty stomach before meals is 2~3 times higher than that of taking medicine after meals, so it will greatly reduce the efficacy, and may also lead to the resistance of sensitive bacteria to fludol or even similar antibacterial drugs.
matters need attention
1. Norfloxacin should be taken on an empty stomach and drink 250ml at the same time.
2. As eserichia coli is frequently resistant to norfloxacin, urine samples should be taken before administration, and medication should be adjusted according to the bacterial susceptibility results.
3. Cryalliuria can occur when high dose application or urine pH value is above 7. In order to avoid the occurrence of crystalline urine, it is advisable to drink more water and maintain a urine volume above 1200ml.
4. In patients with renal function decline, the drug dose should be adjusted according to the renal function.
5. The application of fluoroquinolones can produce moderate and severe photosensitivity reactions. Excessive exposure to sunlight should be avoided and medication should be stopped during the application.
6. glucose-6-phosphate dehydrogenase deficiency patients taking this product, very few may occur hemolysis reaction.
7. quinolones including this product can cause the aggravation of myasthenia gravis symptoms, respiratory muscle weakness and life-threatening. The application of quinolones in patients with myasthenia gravis should be particularly cautious.
8. When liver function is decreased, if it is severe (cirrhosis ascites), it can reduce drug clearance, blood drug concentration increases, especially when liver and kidney function decreases, it is necessary to weigh the advantages and disadvantages, and adjust the dosage.
9. patients with original central nervous system diseases, such as epilepsy and history of epilepsy should avoid the application, there are indications to carefully weigh the advantages and disadvantages after the application.
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