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What Are You Looking For?
Levamisole hydrochloride is the levorotatory form of tetraimidazole, which selectively inhibits succinate dehydrogenase in the muscle of worms, so that fenugreek cannot be reduced to succinate, thus affecting the anaerobic metabolism of worms' muscle and decreasing the energy production, and it is a common parasiticides.
Item NO.:
CAS NO. 16595-80-5Color:
White to pale yellow, crystalline powderPackage:
25 Kg/DrumDescription
Levamisole Hydrochloride is a white to almost white crystalline powder and is an anthelmintic, biological response mediator. It is soluble in water, methanol, ethanol and glycerol, slightly soluble in chloroform and ether; insoluble in acetone. It is stable under acidic conditions, but easily decomposed under alkaline conditions.
Specification
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Item |
Specification |
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Description |
White or almost white crystalline powder |
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Specific optical rotation |
Calculated on the dried basis,-121°~~-128° |
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Infrared identification |
The infrared absorption spectrum is concordant with the spectrum obtained from Levamisole Hydrochloride RS |
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Identification by Specific optical rotation |
Complies with the test for Specific optical rotation |
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Chloride identification (a) |
Positive |
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Appearance of solution |
Solution is clear and not more intensely coloured than reference solution Y7 |
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PH |
3.0～4.5 |
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Impurity A |
Not more than 0.2% |
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Impurity B |
Not more than 0.2% |
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(HPLC) |
Impurity C |
Not more than 0.2% |
| Related substances |
Impurity D |
Not more than 0.2% |
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Impurity E |
Not more than 0.2% |
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Any unspecified impurity |
Not more than 0.10% |
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Total impurities |
Not more than 0.3% |
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Loss on drying |
Not more than 0.5% |
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Heavy metals |
Not more than 20ppm |
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Sulfated ash |
Not more than 0.1% |
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Assay |
It contains not less than 98.5%and not more than 101.0%of Levamisole Hydrochloride (C11H13CIN₂S).calculated on the dried basis |
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Application
Levamisole can regulate immune function, the main effect on T lymphocytes, to induce T cells early differentiation, mature into functional T cells, thus make T cells ht function is normal, can also strengthen the phagof macrophages, chemotaxis, to improve the activity of natural killer cells, produce endogenous interferon, improve the immune function make its normal, effectively prevent pneumonia disease progression, improve cough, lung sounds and other symptoms. In addition, after the immune function of children is weakened, through the use of levamidazole hydrochloride, it can increase the total complement content in the blood, especially the yield of IgG and IgA, so as to improve the immune effect of the respiratory tract, and play a role in virus resistance and bacterial infection prevention. Levamisole can not only regulate immunity, but also restore immunity. The abnormal humoral immune function can show bidirectional regulation, so that it tends to normal development, and help the low cellular immune function to return to normal.As an anthelmintic drug, it is suitable for the treatment of animal roundworm, hookworm, etc. Levamisole is about twice as active as a racemate and has less toxicity and side effects. Levamisole can paralyze the muscles of the worm. Mainly used for roundworm, hookworm, malworm infection.
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