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What Are You Looking For?
Colistin sulfate is produced by Mucor polymyxa and has a potent antibacterial effect against Gram-negative bacteria. It is used to treat intestinal diseases caused by Gram-negative bacteria and is more effective when combined with sulfadiazine.
Item NO.:
CAS NO. 1264-72-8Color:
White to Off-White powderPackage:
25Kg/DrumDescription
Colistin Sulfate is a white or almost white powder with no odor and a bitter taste. It is attracted to moisture and is easily soluble in water, slightly soluble in methanol and ethanol, and almost insoluble in acetone and ether. The free base has limited solubility in water.
Specification
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Item |
Specification |
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Characters |
Appearance |
White or almost white,hygroscopic powder |
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Solubility |
Freely soluble in water,practically insoluble in acetone and in ethanol (96%) |
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ldentification |
HPLC identification |
The peaks due to polymyxin E1 and polymyxin E2 in the chromatogram obtained with the test solution are similar in retention time to the corresponding peaks in the chromatogram obtained with reference solution (a) |
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Sulfate identification |
It gives reaction (a)of sulfates |
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pH |
4.0～6.0 |
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Sum of polymyxins E4 and E2-Val ≤3.0% |
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Polymyxin E6 ≤4.5% |
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Polymyxin E2-I ≤2.5% |
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HPLC composition |
Polymyxin E3 ≤5.5% |
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Polymyxin E1-Nva ≤4.5% |
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Polymyxin E1-I ≤8.5% |
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Polymyxin 2,3-dehydro E1 ≤1.5% |
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Polymyxin E1-7MOA ≤5.0% |
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Sum of polymyxins E1,E2,E3,E4,E6,E1-7MOA, E1-1,E1-Nva,E2-I,E2-Val and 2,3-dehydro E1 |
≥86.0% |
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Impurity B ≤4.0% |
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Any other impurity |
≤2.5% |
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Related substances |
NMT 4 such impurities exceed 1.0% |
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Total impurities ≤11.0% |
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Sulfate (Dried substance) |
16.0%～18.0% |
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Loss on drying |
≤3.5% |
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Sulfated ash |
≤1.0% |
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Assay(Dried substance) |
≥19000 |U/mg |
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Application
Nnarrow spectrum bactericide. Escherichia coli, Salmonella, patentella, pastelium, dysentery, brucella, vibrio, pyomas aeruginosa gram negative bacteria have strong antibacterial effect, including the bactericidal effect of P. aeruginosa and vibrio is strong, sterilization mechanism is damage bacterial cell membrane, increase its permeability, make bacteria amino acid, purine, pyrimidine, K + leakage, can also affect the cytoplasm and ribosome function, lead to bacterial death. Bacteria are not easy to develop resistance to this drug, with complete cross-resistance with polymyxin B, but no cross-resistance with other antimicrobial drugs, and all Gram-positive bacteria and Proteobacteria, Brucella and Serratia are resistant to this product. Colocicactin sulfate is mainly used to treat intestinal infections caused by gram-negative bacilli and external treatment of pyomonas aeruginosa infection caused by burns and trauma. Make feed drug additive, have growth-promoting effect.It is an antibiotic drug, used for the treatment of intestinal diseases caused by gram-negative bacteria, and has a certain growth-promoting effect. It is mainly used for sensitive bacteria infection, such as sepsis, acute enteritis, urinary tract infection, etc
Characteristics of colistin sulfate
(1) has an extremely strong resistance to gram-negative bacilli. In particular, it has specific developmental obstacles for E. coli, Salmonella and P. aeruginosa.
(2) It has the effect of killing bacteria. By hindering the selective permeability of the cell membrane, the bacteria die.
(3) there is little problem of drug resistance. No factor R factor resistance was found.
(4) Synergized with anti-Gram-positive bacteria drugs. Combined with bacitracin zinc, flavamycin, sulfonamides, semi-synthetic penicillin, gentamicin, its effect is even better.
(5) No residue. When administered orally, it is hardly absorbed by the gut, but when injected intramuscularly, the blood is well absorbed, so there is no need to worry about the residues in the animal products.
(6) Promote the growth of livestock and poultry, prevent and control livestock and poultry infectious enteritis and so on.
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